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Once an API has demonstrated its potential through clinical trials, pharmaceutical companies must then ensure that it can be manufactured at scale without compromising its quality. This step often involves the establishment of Good Manufacturing Practices (GMP), which dictate the standards for the production of APIs to guarantee that they meet the necessary quality parameters.
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Penicillin, a pioneer among antibiotics, once had a production process that caused significant environmental pollution. In recent years, with the application of eco-friendly pharma intermediates, penicillin production has become cleaner and more efficient. For instance, using biocatalysis instead of chemical catalysis not only increases penicillin yield but also significantly reduces wastewater and gas emissions, achieving green production processes. Additionally, optimizing fermentation techniques has improved the biosynthesis efficiency of penicillin, reduced chemical synthesis steps, and lowered energy and resource consumption.
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